KING EDWARD MEMORIAL HOSPITAL

Seth Gordhandas Sunderdas Medical College

Acharya Donde Marg, Parel,
Mumbai 400 012. India.
Tel.: 91-22-2410 7000 Fax: 91-22-2414 3435

Clinical Pharmacology

Courses Offered – 2017

  1. DM Clinical Pharmacology – 3 seats
  2. PhD Clinical Pharmacology- Maharashtra University of Health Sciences
  3. Fellowship in Drug Development – 2 seats- Maharashtra University of Health Sciences
  4. PhD – Applied Biology – Mumbai University
  5. MSc- Applied Biology – Mumbai University
  6. Two week hands training course in Therapeutic Drug Monitoring
  7. One week hands on training course in Adverse Drug Reactions Monitoring
  8. Undergraduate Certificate Course in Clinical Research- 35 seats

Facilities, Equipments & Special services

Facilities

  • 40 bedded ward (of this 26 beds at the Kasturba Hospital for infectious diseases)
  • 3 bedded state of the art Phase 1 unit
  • Therapeutic Drug Monitoring lab and patient care services
  • Pharmacogenetics lab and patient care services

For Student

Updates

Await details of Medical Writing workshop for Postgraduate Medical Students and Junior Faculty – May 2015

Awards & Honors

2017

    1. Awards won- 2017
      10 th and 11 th February 2017- At the 10 th annual meeting of the Indian Society for Clinical Research,Mumbai

Best paper award- oral presentations

1- Survey of Public Knowledge and Perceptions about Clinical Research in Mumbai [awarded to Ashnik Chauhan- undergraduate student]

2-Association between genetic polymorphisms of CYP2C9 & VKORC1 and safety & efficacy of Warfarin:
Results of a 5-year audit [awarded to Dr Mansij Biswas – Speciality Medical Officer]

Best paper award- poster presentations

1- A three year analysis of retracted articles from Pubmed indexed core clinical journals- [awarded to Dr Nayan Chaudhari, First year DM resident]

2- Do Clinical Trials conducted in India match its healthcare needs? An audit of the Clinical Trials Registry of India [CTRI]- [awarded to Dr Nithya Gogtay, Additional Professor]

 

2016

  1. First prize for best paper at the Indian Society for Clinical Research annual conference. Jan 2016. For the paper entitled ” Does audiovisual recording improve understanding among research participants” . Authors- Figer B, Chaturvedi M, Thaker S, Gogtay NJ, Thatte UM.
  2. An audit of approval letters issued by the Drug Controller General of India (DCGI) to the ethics committees in India. Authors: Bhide SS, Katkar JV,Maurya MR, Gogtay NJ,Thatte UM. Awarded the best poster at the annual meeting of the Indian Society of Clinical Research, Jan 2016

2015

  1. Best poster award at the WAME International Conference for Medical Journal Editors, New Delhi 1-4 October 2015.
    • Poster entitled ” An audit of randomized controlled trials [RCTS] published in two high impact factor journals in 2013 to assess compliance with CONSORT statement 2010. Authors- Gada P, Susvirkar A, Figer B, Gogtay NJ, Thatte UM

2014

  1. Mr Agastya Belur won the poster prize for Epidemiology session 1 at Groningen, Netherlands. Project title- The demographics of animal bite victims and management practices in a tertiary care institute in Mumbai. Poster presented at the 21st International Student Congress On (bio)Medical Sciences [ISCOMS, 2014]

2012

  1. KVPY award of the Department of Science and Technology, Government of India, for the year 2011, won by Miss Samruddhi Dani, 2nd MBBS (undergraduate student) for her work on ” Enhancing blood transfusion safety using haemovigilance”
  2. Kannan S et al. Association of genetic polymorphisms of CYP2C19, ABCB1, P2Y12 and Prakriti with response to clopidogrel. Best poster award at the monthly meeting of the staff society, March 2012.
  3. Taur S et al – 3rd Prize in poster- PG presentation in Staff Society Meeting – 27 Feb 2012 – “Pharmacogenomics of antiepileptic drugs: role of ABCB1, CYP2C9 and CYP2C19 in optimizing therapy”
  4. Momin S et al – 3rd prize in oral – PG presentation in Staff Society Meeting – 27 Feb 2012 – “Pharmacokinetics of primaquine in pediatric population” (study in collaboration with the Department of Pediatrics)

For Patient

OPDs

Therapeutic Drug Monitoring: Friday: 9.00am to 11.30am
Saturday: 9.00am to 11.30am
Malaria OPD in KEM Hospital: Daily – 9.00am to 12.00 noon

Other

Centres

  • ICMR centre for Advanced Research in Clinical Pharmacology
  • WHO Special Centre for Adverse Drug Reactions Monitoring
  • DCGI Centre for Adverse Drug Reactions Monitoring
  • Central Drug Research Institute (CDRI) Clinical Pharmacology Unit
  • Integrated Systems of Medicine Research Centre
  • Liposome Clinical Pharmacology Centre, Govt. of India
  • Department of Biotechnology, Government of India Training centre for Clinical Research

Funding

  1. Municipal Corporation of Greater Mumbai.
  2. Indian Council of Medical Research (ICMR)
  3. World Health Organization
  4. Pharmaceutical Industries
  5. Department of Biotechnology, Govt of India
  6. Ministry of Health and Family Welfare, Govt of India (Pharmacovigilance grant)
  7. Program for Appropriate Technology (PATH)
  8. National Institutes of Health (NIH), Maryland, USA
  9. Other International Agencies- Johns Hopkins University
  10. Central Drug Research Institute, Lucknow

Faculty

    • Dr. Urmila Thatte – Professor and Head
    • Dr. Nithya Gogtay – Professor (Additional)
    • Dr. Siddharth Deshpande – Assistant Professor

    • Dr Debdipta Bose-First Year DM resident
    • Dr Mahanjit Konwar-First Year DM resident
    • Dr Renju Ravi – Second year DM resident
    • Dr Nayan Chaudhari – Second year DM resident
    • Dr Parvan Shetty – Third year DM resident
    • Dr Amit Birajdar-Specialty Medical Officer
    • Dr Tushar Nishandar-Specialty Medical Officer

 Office Secretaries

  •  Mrs Ujwala Paruleka
  • Miss Priyanka Bhuwad

Technical Staff

  • Pharmacovigilance Program of India – Position of technical Associate vacant
  • Brinal Figer- CSIR project [Research Associate]

Departmental Alumni

  • Dr. Saket Thaker, Roche Pharmaceuticals Ltd
  • Dr S Kannan, batch of 2009, Assistant Professor of Pharmacology at Medical College, Meerut
  • Dr. Balaji More – batch of 2000, now with Merck Limited
  • Dr. Sanath Hegde – batch of 2002, now with Novartis India Ltd
  • Dr. Sanish Davis – batch of 2003, now with Glenmark Pharmaceuticals Ltd
  • Dr. Priti D’Costa – batch of 2007
  • Dr. Santosh Taur
  • Dr. Suresh Ramakrishna – batch of 2008, Assistant Professor, Department of Clinical Pharmacology.
  • Dr Maulik Doshi, Regulatory Affairs, Sun Pharma Ltd

PhD students

    • Ms Shital Bendkhale
    • Mrs Prajakta Gandhe
    • Shri Nitin Mali
    • Shri Prashant Kadam
    • Ms Charulata Godbole
    • Ms. Brinal Figer
    • Dr Mahesh Belhekar

MSc students:

  • Mrs. Mukta Kuyare

Protocol for systematic review for the use of deception in clinical research

Ongoing projects

Ongoing academic studies

  1. A comparative study to assess the quality and data completeness in Industry sponsored versus Investigator Initiated Trial
  2. An audit of Laboratory Parameters to assess nature and extent of screen failures and to determine the reference ranges for Indian participants presenting at a clinical trial site.
  3. Determination of laboratory reference intervals in healthy Indian adults at an academic centre
  4. Survey of Public knowledge and awareness of clinical research in Mumbai
  5. Pharmacoeconomic study for cost effectiveness of genotyping in patients on warfarin therapy with respect to prevention of bleeding episodes.
  6. Association of genetic polymorphisms of cytochrome P450 C19, ABCB1 , P2Y12 and response to the clopidogrel.
  7. Pharmacokinetics-Pharmacodynamics relationship of vancomycin in patients with suspected or proven Gram-positive bacterial infection admitted to medicine intensive care unit of tertiary care hospital
  8. Pharmacokinetics-Pharmacodynamics relationship of vancomycin in children with suspected or proven Gram-positive bacterial infection admitted to Pediatric intensive care unit of tertiary care hospital.
  9. Evaluation of prevalence of mutation in Choloroquine and sulphadoxine- pyrimethamine drug resistance associated with genes in vivax malaria isolate in a tertiary care center in Mumbai by nested- polymerase chain reaction techniques (nPCR)
  10. Geographic variation in the clinical manifestations, treatment and outcome of vivax malaria in three Indian states
  11. A study comparing published protocols and/or trial registry entries with published papers from two high impact factor journals
  12. A Case-Control study to assess the prevalence and association of different Paraoxonase 1 (PON-1) polymorphisms and its activity with Coronary Artery Disease (CAD)
  13. Assessment of modulation of activity of Paraoxonase-1 (PON-1) by statins in patients requiring statin therapy

 

Sponsored studies

 

   Govt. sponsored

  1. CSIR Sponsored Project entitled ’Advanced Drug Delivery Systems’
  2. Association of genetic polymorphisms of CYP2C19, ABCB1 and P2Y12 with response to clopidogrel in normal healthy participant
  3. Evaluation of host immune response and parasite proteome in patients with severe/complicated malaria
  4. PCR validation of microscopy results and genomic analyses of host inflammatory genes associated with severe and non-severe malaria
  5. B cell phenotyping, TLR4 expression determination, anti-parasite antibody profiling of serum samples and epidemiological data collection of patients diagnosed with malaria and comparison with healthy controls and non malarial-fever participants at a tertiary referral centre
  6. Modelling malaria prevalence in Mumbai
  7. Evaluation of the activity of aldehyde oxidase activity in normal, healthy adult Indian population by phenotyping

Pharma sponsored

  • A Phase III, Multicenter, open label , Randomized Study of Bovine Rotavirus Pentavalent Vaccine (BRV-PV) to Evaluate Lot-to-Lot Consistency and to Investigate Potential Interference with Routine UIP Vaccinations in Healthy Infants in India.
  • Immunogenicity and Safety of a Single Dose or Two Doses Given 28 Days Apart of a Quadrivalent Influenza Vaccine Administered via the Intramuscular Route in Subjects Aged 6 Months or Older in India

Recent Publications

YEAR-2017

    1. Gogtay NJ, Thatte UM. Survival analysis. J Assoc Phy Ind 2017; 65: 80-84
    2. Gogtay NJ, Deshpande SP, Thatte UM. Principles of regression analysis. J Assoc Phy Ind 2017; 65: 48-52.
    3. Gogtay NJ, Thatte UM. Principles of correlation analysis. J Assoc Phy Ind 2017; 65: 78-81.
    4. Gogtay NJ, Renju Ravi, Thatte UM. Regulatory requirements for clinical trials in India” what academicians need to know. Indian J Anaesth 2017; 61: 192-9.
    5. Thaker SJ, Gandhe PP, Godbole CJ, Bendkhale SR, Mali NB, Thatte UM, Gogtay NJ. A prospective study to assess the association between genotype, phenotype, and Prakriti in individuals on phenytoin monotherapy. Journal of Ayurveda and Integrative Medicine 2017; [xxx] 1-5. In press.
    6. Gogtay NJ, Thatte UM. Statistical evaluation of Diagnostic tests- part 1. J Assoc Phy Ind 65; 80-4
    7. Gogtay NJ, Thatte UM. Statistical evaluation of Diagnostic tests-part 2. J Assoc Phy Ind 65; 86-91.
    8. Ray S, Patel KS, Venkatesh A, Chatterjee G, Ansari NN, Gogtay NJ, Thatte UM et al. Quantitative proteomic analysis of Plasmodium vivax induced alterations in human serum during the acute and convalescent phases of infection. Scientific Reports 2017; 7: 4400/DOI: 10.1038/S41598-017-04447-5
    9. Gogtay NJ, Thatte UM. Number needed to treat. J Assoc Phy Ind 2017; 65: 90-4
    10. Kshirsagar NA, Gogtay NJ, Garg BS, Deshmukh PR, Rajgor DD, Kadam VS, Thakur PA, Gupta A, Ingole NS, Lazdins-Helds JK. Efficacy and tolerability of treatment with single doses of diethylcarbamazine (DEC) and DEC plus albendazole (ABZ) for three consecutive years in lymphatic filariasis: a field study in India. Parasitol Res 2017;Aug 7. doi: 10.1007/s00436-017-5577-9.
    11. Wandalkar P, Gandhe P, Pai A, Limaye M, Chauthankar S, Gogtay NJ, Thatte UM. A study comparing trial registry entries of randomized controlled trials with publications of their results in a high impact factor journal: The Journal of the American Medical Association. Perspect Clin Res 2017;8:167-71.
    12. Chaturvedi M, Gogtay NJ, Thatte UM. Do clinical trials conducted in India match its healthcare needs? An audit of the Clinical Trials Registry of India. Perspect Clin Res 2017;8:172-5.
    13. Gogtay NJ, Thatte UM. An Introduction to Meta-analysis. J Assoc Phy Ind 2017; 65: 78-85.

Accepted for Publication

    1. Ray S, Patel SK, Venkatesh A, Chatterjee G, Ansari NN, Gogtay NJ, Thatte UM et al. Quantitative proteomics analysis of Plasmodium vivax induced alterations in human serum during the acute and convalescent phases of infection. Accepted for publication in Scientific Reports
    2. Susvirkar A, Gada P, Figer B, Thaker S, Thatte UM and Gogtay NJ. An assessment of the compliance of the Randomized Controlled Trials [RCTs] published in two high impact factor journals in 2013 with CONSORT statement 2010. Nat Med J Ind 2017; in press.
    3. Mahajan M,  Deshpande S, Gogtay NJ, Thatte UM. An analysis of completeness and quality of adverse drug reaction reports at an Adverse Drug Reaction monitoring centre in Western India’. Accepted for publication in Perspectives in Clinical Research.

YEAR-2016

    1. Jalgaonkar SV, Bhide SS, Tripathi RK, Shetty YC, Marathe PA, Katkar J, Thatte UM (2016) An Audit of Protocol Deviations Submitted to an Institutional Ethics Committee of a Tertiary Care Hospital. PLoS ONE 11(1): e0146334. doi:10.1371/ journal.pone.0146334
    2. S. Kannan, T. Modi, S. Bendkhale, D. Kulkarni, N.J. Gogtay and U.M. Thatte Bentham Science Publishers Association of Genetic Polymorphisms of CYP2C9 and VKORC1 with Bleeding Following Warfarin: A Case-control Study,* Current Clinical Pharmacology, 11, 000-000 1 1574-8847/16
    3. Gogtay NJ, Kapileshwar SR, Shah SU, Bendkhale SR, Ramakrishna S, Sridharan K, Thelma BK, Thatte UM & Kshirsagar NA.
      Evaluation of Cytochrome CYP2E1 polymorphisms in healthy, adult Western Indians and patients with antituberculous drug-induced hepatotoxicity. Indian J Pharmacol 2016; 4891): 42-6.
    4. Gogtay NJ, Sridharan K. Therapeutic Nucleic Acids- current clinical status. B J Clin Pharmacol 2016; April 25, ahead of print
    5. Gogtay NJ. Adieu… J Postgrad Med 2016; 62: 67-8
    6. Bhide SS, Jalgaonkar SV, Katkar JV, Shetty YC, Tripathi RK, Marathe PA, Thatte UM. Impact of recent regulatory notifications on an institutional ethics
      committee. Indian J Med Ethics. 2016 Jun 19;-(-):1-5. [Epub ahead of print]
    7. Tripathi RK, Marathe PA, Kapse SV, Shetty YC, Kamat SK, Thatte UM. Serious Adverse Events Reports: Analysis and Outcome of Review by an Institutional Ethics Committee of a Tertiary Care Hospital in Mumbai, India. J Empir Res Hum Res Ethics. 2016 Jun 27.[Epub ahead of print]
    8. Hazra A, Gogtay N. Biostatistics Series Module 3: Comparing Groups: Numerical
      Variables. Indian J Dermatol. 2016 May-Jun;61(3):251-60
    9. Ray S, Patel SK, Venkatesh A, Bhave A, Kumar V, Singh V, Chatterjee G, Shah
      VG, Sharma S, Renu D, Nafis N, Gandhe P, Gogtay N, Thatte U, Sehgal K, Verma S,
      Karak A, Khanra D, Talukdar A, Kochar SK, S B V, Kochar DK, Rojh D, Varma SG,
      Gandhi MN, Srikanth R, Patankar S, Srivastava S. Clinicopathological Analysis and
      Multipronged Quantitative Proteomics Reveal Oxidative Stress and Cytoskeletal
      Proteins as Possible Markers for Severe Vivax Malaria. Sci Rep. 2016 Apr
      19;6:24557
    10. Hazra A, Gogtay N. Biostatistics Series Module 2: Overview of Hypothesis Testing. Indian J Dermatol. 2016 Mar-Apr;61(2):137-45
    11. Hazra A, Gogtay N. Biostatistics Series Module 1: Basics of Biostatistics. Indian J Dermatol. 2016 Jan-Feb;61(1):10-20
    12. Gogtay NJ, Thatte UM. Clinical research- a primer. J Assoc Phy Ind 2016; 64: 62-63.
    13. Deshpande S, Gogtay NJ, Thatte UM. Data Types. J Assoc Phy Ind 2016; 64: 64-65.
    14. Deshpande S, Gogtay NJ, Thatte UM. Measures of central tendency and dispersion. J Assoc Phy Ind 2016; 64: 64-66.
    15. Gogtay NJ, Deshpande SP, Thatte UM. Normal distribution, p value and confidence intervals. J Assoc Phy Ind; 64:
    16. Gogtay NJ and Thatte UM. Samples and their size – the bane of researchers [Part I]. J Assoc Phy Ind 2016; 64: 66-69
    17. Gogtay NJ and Thatte UM. Samples and their size – the bane of researchers [Part II]. J Assoc Phy Ind 2016; 64: 68-71.

    YEAR-2015

    1. Thatte U, Chiplunkar S, Bhalerao S, Kulkarni A, Ghungralkar R, Panchal F, Vetale S, Teli P, Kumbhar D, Munshi R. Immunological & metabolic responses to a therapeutic course of Basti in obesity. Indian J Med Res. 2015 Jul;142(1):53-62. doi: 10.4103/0971-5916.162099.
    2. Lalwani S, Agarkhedkar S, Gogtay N, Palkar S, Agarkhedkar S, Thatte U, Vakil H, Jonnalagedda R, Pedotti P, Hoyle M, Bhusal C, Arora A. Safety and immunogenicity of an investigational meningococcal ACWY conjugate vaccine (MenACWY-CRM) in healthy Indian subjects aged 2 to 75 years. Int J Infect Dis. 2015 Sep;38:36-42. doi: 10.1016/j.ijid.2015.07.003. Epub 2015 Jul 9.
    3. Bavdekar SB, Gogtay NJ.
      Writing an abstract for a research manuscript: providing an honest, succinct and complete summary. J Assoc Phy Ind 2015; 63: 64-7.
    4. Thakkar AN, Karande S, Bala N, Sant H, Gogtay NJ, Sholapurwala R.
      Is anxiety more common in school students with newly diagnosed specific learning disabilities? A cross-sectional questionnaire-based study in Mumbai, Maharashtra, India.
      J Postgrad Med. 2015 Oct 20. doi: 10.4103/0022-3859.167663. [Epub ahead of print] PubMed PMID: 26482116.
    5. Gogtay NJ & Ferner RE. Mefloquine for malarial prophylaxis in military personnel. BMJ 2015; 351: h5797
    6. Thaker SJ, Figer B, Gogtay NJ, Thatte UM. An audit of consent refusals in clinical research at a tertiary care centre in India. J Postgrad Med 2015; 61: 257-63.
    7. Ranganathan P, Gogtay NJ. Improving peri-operative patient care: the surgical safety checklist. J Postgrad Med 2015; 61: 73-4.
    8. Ray S, Kumar V, Bhave A, Singh V, Gogtay N, Thatte U, Talukdar A, Kochar SK,Patankar S, Srivastava S. Proteomic analysis of Plasmodium falciparum induced alterations in humans from different endemic regions of India to decipher malaria pathogenesis and identify surrogate markers of severity. J Proteomics. 2015 May 14. pii: S1874-3919(15)00232-8. doi:10.1016/j.jprot.2015.04.032. [Epub ahead of print]
    9. Thaker SJ, Sinha RS, Gogtay NJ & Thatte UM. Evaluation of inter rater agreement between three causality scales used in Pharmacovigilance” Jr Pharmacol PharmacoTher – accepted for publication.
    10. Jasani B, Kannan S, Nanavati R, Gogtay NJ & Thatte UM. An Audit of Colistin Use in Neonatal Sepsis from a Tertiary Care Centre of a Resource Limited Country. Ind Jr Med Res 2015; accepted for publication.
    11. Kuyare, MS, Marathe, PA, Kuyare, SS and Thatte UM. Perceptions and Experiences of Community Members Serving on Institutional Review Boards: A Questionnaire Based Study. HEC Forum; 20 Jan 2015
    12. Sengupta A, Ghosh S, Pathak S, Gogtay N, Thatte U, Doshi M, Sharma S, Sonawat H. Metabolomic analysis of urine samples of vivax malaria in-patients for biomarker identification. Metabolomics March 2015. DOI 10.1007/s11306-015-0791-x

    YEAR-2014

      1. Kuyare SS, Marathe PA, Shetty YC, Kamat SK, Katkar JV, Thatte UM “Projects Not Initiated by Investigators: A Retrospective Analysis of the Queries Raised by the Institutional Ethics Committees of a Teaching Hospital” J Postgrad Med. January-March; Volume 60(1):46-50
      2. Yadav S, Kannan S, Vaideeswar P, Gogtay N, Thatte U. Indian J Pathol Microbiol. 2014 Jan-Mar;57(1):152-3.
      3. SR Taur, NB Kulkarni, PP Gandhe, BK Thelma, SH Ravat, NJ Gogtay, UM Thatte. Association of polymorphisms of CYP2C9, CYP2C19, and ABCB1, and activity of P-glycoprotein with response to anti-epileptic drugs. Journal of Postgraduate Medicine, 60(3): 265-269.
      4. Kuyare MS, Taur SR, Thatte UM Establishing Institutional Research Ethics Committees: Challenges and Solutions – A Review of Literature. Indian Journal of Medical Ethics, 11(3): 181-185.
      5. Kannan S, Gogtay N, Thatte UM. Interaction of calcium channel blockers and grapefruit juice in healthy adults (Protocol). Cochrane Database of Systematic Reviews 2014, Issue 12. Art. No.: CD011452. DOI: 10.1002/14651858.CD011452.
      6. Taur SR, Karande S, Saxena AA, Gogtay NJ, Thatte UM. Use of computerized tests to evaluate psychomotor performance in children with specific learning disabilities in comparison to children without any learning disability. Indian Journal of Medical Research, 140, November 2014, pp 644-648
      7. Gogtay NJ, Nagpal A, Mallad A, Patel K, Stimpson SJ, Belur A & Thatte UM. Cost calculations in health care- a reply. Ind Jr Med Res 2014; 140: 568-69.
      8. Bang V, Mallad A, Kannan S, Bavdekar SB, Gogtay NJ, Thatte UM. Awareness about and views of parents on off label drug use in children. Int J Risk Saf Med. 2014 26(2):61-70.
      9. Karande S & Gogtay NJ. Impact of the midday meal scheme in India. J Postgrad Med 2014; 60: 113-5.
      10. Gogtay NJ, Thatte UM, Thaker SJ & Deshpande S. Need for and use of guidelines for reporting qualitative research. (letter to editor on paper by Mishra N et al). Ind Jr Med Res 2014; accepted for publication
      11. Thaker SJ, Gogtay NJ, Thatte UM. Pharmacoepidemiology: The essentials. Clinical Epidemiology and Global Health 2014; xxx 1-6
      12. Gogtay NJ, Nagpal A, Mallad A, Patel K, Stimpson SJ, Belur A, Thatte UM. Demographics of animal bite victims and management practices in a tertiary care institute in Mumbai, India. Indian J Med Res 2014; 139: 59-62.- Link to Study
      13. Patwardhan S, Gogtay NJ, Thatte U, Pramesh CS. A retrospective study comparing the quality and completeness of data documentation in an investigator initiated study versus an industry sponsored study. Indian J Med Ethics 2014; 11(1): 19-24.
      14. Gogtay NJ, Mali NB, Iyer K, Kadam PP, Sridharan K, Shrimal D, Thatte UM. Evaluation of cytochrome P450 2D6 phenotyping in healthy adult Western Indians. Ind. J. Pharmacol. 2014;46:266-9.
      15. Rajgor DD, Gogtay NJ, Kadam VS, Kocharekar MM, Parulekar MS, Dalvi SS, Vaidya AB, Kshirsagar NA. Anti relapse efficacy of various primaquine regimens for Plasmodium vivax. Malaria Red and Treatment 2014; 2014; doi. 10.1155/2014/347018/
      16. N.J. Gogtay, U.M. Thatte, S. Thaker & S. Deshpande Need for & use of guidelines for reporting qualitative research Indian J Med Res 140, December 2014, pp 788-789

YEAR-2013

      1. “Evaluation of factors that motivate participants to consent for non-therapeutic trials in India
        Maulik S Doshi, Shaunak P Kulkarni, Canna J Ghia, Nithya J Gogtay, Urmila M Thatte
        J Med Ethics Published Online First: 8 March 2013 doi:10.1136/medethics-2012-100755”
      2. Kalekar SA, Munshi RP, Bhalerao SS, Thatte UM. Insulin sensitizing effect of 3 Indian medicinal plants: An in vitro study. Indian J Pharmacol 45:30-3
      3. Gogtay NJ, Thatte UM, DasGupta B, Deshpande S Use of the WOMAC™ questionnaire in Mumbai and the challenges of translation and cross cultural adaptation, IJME, X (1): 33-35.
      4. Taur Santosh, Kulkarni Namrata, Gogtay Nithya, Thatte Urmila. An audit of therapeutic drug monitoring services of anticonvulsants at a tertiary care hospital in India, Therapeutic Drug Monitoring, Publ ahead of print 12 February 2013 doi: 10.1097/FTD.0b013e3182803d16
      5. Kannan S, Deshpande SP, Gogtay NJ & Thatte UM. Policy of reviewing statistics in Indian medical and surgical journals. Jr Pharmacol & Pharmacother 2013; 4: 139-40. DOI:10.4103/0976-500X.110897
      6. Kulkarni SP, Shah SR, Kadam PP, Kannan S, Hase NK, Shetty PP, Thatte UM & Gogtay NJ. Pharmacokinetics of a single dose (15 mg) Primaquine in patients with chronic kidney disease. Ind Jr Pharmacol 2013; (accepted, in press)
      7.  Nithya Gogtay, Sridharan Kannan, Urmila M Thatte, Piero L Olliaro, David Sinclair. Artemisinin-based combination therapy for treating uncomplicated Plasmodium vivax malaria. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD008492. DOI: 10.1002/14651858.CD008492.pub3″
      8. Kalekar A Samidha, Munshi P Renuka, Thatte M Urmila. Do plants mediate their anti-diabetic effects through anti-oxidant and anti-apoptotic actions? an in vitro assay of 3 Indian medicinal plants. BMC Complementary and Alternative Medicine.2013, 13:257. DOI: 10.1186/10.1186/1472-6882-13-257
      9. ND Karnik, K Sridharan, SP Jadhav, PP Kadam, RK Naidu, RD Namjoshi, V Gupta, MS Gore, PV Surase, PR Mehta, JA Gogtay, UM Thatte, NJ Gogtay. Pharmacokinetics of colistin in critically ill patients with multidrug-resistant Gram-negative bacilli infection. European Journal of Clinical Pharmacology DOI 10.1007/s00228-013-1493-9. (2013) 69:1429–1436
      10. MS Doshi, SP Kulkarni, Canna Ghia, NJ Gogtay, UM Thatte Evaluation of factors that motivate participants to consent for non-therapeutic trials in India. J Med Ethics 39(6):391-6
      11. Kulkarni SP, Shah SR, Kadam PP, Kannan S, Hase NK, Shetty PP, Thatte UM, Gogtay NJ. Pharmacokinetics of a single dose (15 mg) Primaquine in patients with chronic kidney disease. Indian J of Pharmacol, 45(4): 330-333.
      12. Bhalerao MS, Bolshete P, Swar BD, Bangera TA, Kolhe V, Tambe MJ, Wade M, Bowate S, Sonje U, Gogtay NJ, Thatte UM. A cross-sectional study to measure extent of use and Assess the Patients satisfaction with complementary and alternative Medicine (CAM) in four chronic diseases in a tertiary referral centre in India. NMJI, 26(2):75-78
      13. Doshi MS, Naik AA, Mehta MR, Gogaty NJ, Thatte UM, Menon M.Three-way, three-period, crossover bioequivalence study of single oral dose of three brands of 300 mg phenytoin sodium tablets marketed in India, on healthy Indian human volunteers. Journal of Pharmacology and Pharmacothrerapeutics http://www.jppfirst.com/three-way-three-period-crossover-bioequivalence-study-single-oral-dose-three-brands-300-mg-phenytoin

YEAR-2012

      1. Shetty Y, Marathe P, Kamat S and Thatte U. Site monitoring by an IEC IJME, 2012;IX:22-6.
      2. Srivastava Rajneesh, Ray Sandipan, Vaibhav Vineet, Gollapalli Kishore, Jhaveri Tulip, Taur Santosh, Dhali Snigdha, Gogtay Nithya, Thatte Urmila, Srikanth Rapole, Srivastava Sanjeeva, Serum profiling of leptospirosis patients to investigate proteomic alterations, Journal of Proteomics (2012), doi: 10.1016/j.jprot.2012.04.007
      3. Ray S, Kamath KS, Srivastava R, Raghu D, Gollapalli K, Jain R, Gupta SV, Ray S, Taur S, Gogtay NJ, Thatte UM, Rapole S, Patankar S, Srivastava S. Serum proteome analysis of vivax malaria: An insight into the disease pathogenesis and host immune response Journal of Proteomics [http://dx.doi.org/10.1016/j.jprot.2011.10.018], 75:3063-80
      4. Thatte UM, Gogtay NJ, Kannan S, Oak S Title: Access to medicines for orphan diseases- experiences in the management of a case of Fasciola Hepatica in Mumbai, India. NMJI; VOL. 25, NO. 4, 234-35
      5. Sandipan Ray; Durairaj Renu; Rajneesh Srivastava; Kishore Gollapalli; Santosh Taur; Tulip Jhaveri; Snigdha Dhali; Srinivasarao Chennareddy; Ankit Potla; Jyoti Bajpai Dikshit; Rapole Srikanth; Nithya Gogtay; Urmila Thatte; Swati Patankar; Sanjeeva Srivastava, Serum Proteome Analysis of Falciparum and Vivax Malaria to Decipher Host Immune Response, Disease Pathogenesis, and Identify Surrogate Protein Markers”. PLOS One, 7 (8) e41751doi 10.1371journal.pone.0041751
      6. Gogtay NJ, Thatte UM, Kshirsagar NA, Leav B, Molrine D, Martin V, Wiggin H, Cheslock P, Sharma H, Barde P, Mangrule S, Kapre SV, Kulkarni PS. Safety and Pharmacokinetics of a Human Monoclonal Antibody to Rabies Virus: A Randomized, Dose-Escalation Phase I Study in Adults, Vaccine , 30: 7315-20
      7. Thakkar AN, Bendkhale SR, Taur SR, Gogtay NJ, Thatte UM. Association of CYP2C9 polymorphisms with phenytoin toxicity in Indian patients. Neurol India 2012; 60(6):577-580
      8. Supriya Bhalerao, Tejashree Deshpande, Urmila Thatte. Prakriti (Ayurvedic concept of constitution) and variations in platelet aggregation. BMC Complementary and Alternative Medicine 2012, 12:248 doi:10.1186/1472-6882-12-248

Read More

Protocols of Systematic Reviews

      1. A systematic review of the use of deception as an intervention in clinical research. read more
      2. The Zagreb versus Essen regime for post exposure prophylaxis of rabies” a systematic review and meta analysis. read more

Wards

      1. Clinical Pharmacology Ward in KEM Hospital (10 Beds)
      2. Clinical Pharmacology Ward for infectious diseases in Kasturba Hospital (25 Beds)
      3. CDRI Ward (10 Beds)

AREAS OF SPECIAL INTEREST AND WORK

      • Tropical diseases
      • Adverse Drug Reactions Monitoring
      • Therapeutic Drug Monitoring
      • Drug Delivery systems
      • Liposomal drug delivery
      • Pharmacogenetics

Trainees and Observers

2011

Amanda Burrage and Mathew Tyler, Undergraduate students from the University of Massachusetts, Boston, USA as part of a collaborative program with Mass Biologics, Boston, Jan- March 2011

2010

Sarah Jo Stimpson and Krunal Patel, April 2010. Undergraduate students from the University of Massachusetts, Boston, USA as part of a collaborative program with Mass Biologics, Boston

Location

First Floor
Multi storeyed building
Seth GS Medical College & KEM Hospital
Mumbai 400012

Contact Details

Executive assistant –
Mrs Ujwala Parulekar,
Miss Priyanka Bhuwad
Tel:91 22 24133767/24174420
Fax: 91 22 24112871

News & Updates

 

Await announcement of short courses on Therapeutic Drug Monitoring and Adverse Drug Reactions Monitoring.

Future Plans

  • Therapeutic Drug Monitoring of Voriconazole
  • Therapeutic Drug Monitoring of Immunosuppressants
  • Warfarin Clinic

For Student

Please contact Dr Urmila Thatte and/or Dr Nithya Gogtay for short research projects to be done during your undergraduate tenure [91 22 24133767/24174420]

For Patient

Levetiracetam [anti epileptic] plasma level measurements will be available from June 2017